Recurring genomic structural variation leads to clonal instability and loss of productivity
نویسندگان
چکیده
منابع مشابه
Loss of the epigenetic tumor suppressor SNF5 leads to cancer without genomic instability.
There is a growing appreciation of the role that epigenetic alterations can play in oncogenesis. However, given the large number of genetic anomalies present in most cancers, it has been difficult to evaluate the extent to which epigenetic changes contribute to cancer. SNF5 (INI1/SMARCB1/BAF47) is a tumor suppressor that regulates the epigenome as a core member of the SWI/SNF chromatin remodeli...
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ژورنال
عنوان ژورنال: Biotechnology and Bioengineering
سال: 2018
ISSN: 0006-3592
DOI: 10.1002/bit.26823